Cancer Cells are resistant to angiogenesis inhibitors?

New studies explain how cancer cells 'eat us alive'

This new study seems to say at least 3 things:

1. Its not the cancer that directly causes cachexia, its the stromal cells or fibroblast dying rapidly due to the stress induced by cancer cells.
2. Cancer Cells have mitochondria. In a "normal environment" where cancer cells are present together with the fibroblasts, mitochondria are present. THis is in contrast to cancer cell cultures where cancer cells had no mitochondria.
3. Angiogenesis inhibitors may actually make cancer cells more aggressive in causing cachexia, relapse and metastasis.