A new decision has been made by the US FDA disallowing the use of Avastin for breast cancer. This is due to the life-threatening adverse effects of the drug among breast cancer patients.
What happens to those who already endured the side effects of the drug.
Showing posts with label bevacizumab. Show all posts
Showing posts with label bevacizumab. Show all posts
Sunday, December 19, 2010
Sunday, September 05, 2010
Cancer Cells are resistant to angiogenesis inhibitors?
New studies explain how cancer cells 'eat us alive'
This new study seems to say at least 3 things:
1. Its not the cancer that directly causes cachexia, its the stromal cells or fibroblast dying rapidly due to the stress induced by cancer cells.
2. Cancer Cells have mitochondria. In a "normal environment" where cancer cells are present together with the fibroblasts, mitochondria are present. THis is in contrast to cancer cell cultures where cancer cells had no mitochondria.
3. Angiogenesis inhibitors may actually make cancer cells more aggressive in causing cachexia, relapse and metastasis.
This new study seems to say at least 3 things:
1. Its not the cancer that directly causes cachexia, its the stromal cells or fibroblast dying rapidly due to the stress induced by cancer cells.
2. Cancer Cells have mitochondria. In a "normal environment" where cancer cells are present together with the fibroblasts, mitochondria are present. THis is in contrast to cancer cell cultures where cancer cells had no mitochondria.
3. Angiogenesis inhibitors may actually make cancer cells more aggressive in causing cachexia, relapse and metastasis.
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